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Clinical Endocannabinoid Deficiency

The Theory 

      As discussed on our page on naturally produced endocannabinoids, their importance and usefulness for many biological functions should not be understated. Many diseases and maladies have been shown to either directly related, or causally linked to imbalances or deficiencies of the endocannabinoid system. 

      Initial theories were proposed in the early 2000’s which were based on clinical evaluations.  Statistical correlations of these evaluations of patients with varying conditions led to the discovery of a general underproduction or imbalance of these ECS compounds.  The findings were quite pronounced In patients with certain pathophysiological syndromes.

      These included, but were not limited to migraines, fibromyalgia and irritable bowel syndrome. The theory of CES (clinical endocannabinoid deficiency) postulates that due to some underlying genetic or congenital malady, complicated by injury or stress, a person may underproduce natural EC’s. The lack of EC’s causes such symptoms as: 

  • lowered pain threshhold
  • digestion disturbance
  • mood disturbance
  • sleep changes 


      In subsequent follow up clinical investigations, it has been repeatedly shown these hypofunctional ECS are directly implicated in many interrelated pathophysiological states.  Inflammation, reproductive and immune system function are all largely affected by the endocannabinoid system.

       This would be a likely reason why millions of people have found relief from supplementing or treating their various conditions with cannabis products.  These include both marijuana and hemp. Natural plant derived cannabinoids have been shown to not only supplement a lacking CBS, but to also work synergystically with your existing system.       

        For example, Many IBS patients have found much relief with cannabis and hemp that is high in CBD for its ability to activate the CB2 receptor.  Similiarly, many patients afflicted with chronic pain or lack of appetite have found strong relief from the other main phytocannabinoid THC.  THC is known for it’s ability to activate receptor CB1.  Research is ongoing and the future is bright for this discipline.

       Another example, Anandamide, one of your naturally produced endogenous EC’s, is largely responsible for much of your ECS function. In fact, there are more receptors in your brain for EC’s like Anandamide than for any other neurotransmitter. The problem is an enzyme known as FAAH whose purpose is to break down EC’s like Anandamide. 

       Here is where exogenous cannabinoids like CBD come in.  CBD (a constituent of hemp) actually blocks FAAH from breaking down your EC’s, leaving you with more naturally.  As a little more background, Anandamide has been shown to activate the same receptors as THC albeit less strongly and shorter acting.  Anandamide is actually called the “bliss chemical” for this reason.


        Just as there are numerous phytocannabinoids (plant-derived cannabinoids), there are numerous endogenous (human-produced) EC’s.  Each one has its unique properties and usages and they work collectively to attain homeostasis.  The good news is that cannabis and its derivatives have been proven to be effective natural treatments for complex issues. 

     In fact, every individual has a different and unique ECS, and will respond differently to various hemp and marijuana derived cannabinoids.  That is why everyone seems to respond differently to these compounds.  Therefore, consulting with a state-licensed physician like ours at Florida Natural Wellness is your ideal route to a comprehensive strategy for treatment.  




  • Humans make our own cannabinoids
  • People who are deficient/abnormal producers show symptoms
  • Supplementing/Medicating with cannabis strongly positively correlates for these patients
  • Consulting with a Licensed MD for a comprehensive treatment strategy is wise and legally necessary!


 –The Florida Natural Wellness Team









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